Research reveals that the brain has its own repair program

Mechanism research reveals that when the "repair package" loaded with DLL4 is delivered to the damaged blood vessels, it can accurately dock and activate the NOTCH ("gap" gene) receptor signaling pathway on vascular cells. The activation of this pathway is closely linked to the repair process of the blood-brain barrier, providing a blueprint for repairing damaged "defense lines". Functional experiments have confirmed that intervening in this pathway can significantly affect the efficiency of vascular repair and the level of neurological function recovery in experimental animals. This means that enhancing this "remote repair express route" is expected to become a new rehabilitation strategy.

Our latest discovery is an endogenous repair signaling cell node that has not been fully understood before, "Yang Qingwu said." The repair of the brain after injury is not chaotic, but a precise process with spatial organization and active instructions. Repair signals can be sent from specific 'command centers' to remotely control the' construction site 'of the damaged area

This study, together with previous findings about the "inflammatory amplifier," provides a more complete panoramic view of the brain's "damage response. Xie Qi, the first author of the paper and a researcher in the neurology department of Xinqiao Hospital, explained that "the brain activates multiple programs almost simultaneously after a stroke, with one side being a local, pro-inflammatory 'destructive' response and the other side being a distant, protective and reparative 'constructive' response. The ultimate outcome of the disease depends on the game between these two forces." This suggests that future treatment strategies need to have the wisdom of "bidirectional regulation", which not only suppresses local "destructive programs" but also enhances remote "repair programs".