The biological clock is a tool we are born with. It can keep us basically taking 24 hours as the behavior cycle. We have regular time intervals for sleeping and eating, but it may also deviate. Even the recognized healthy way of work and rest of going to bed early and getting up early may be a disease.
Scientists call it familial sleep lead syndrome. People with this rare condition go to bed and get up four hours earlier than others.
Early to bed and early to rise may be a good recipe for a healthy life, but for some early risers, it may be an unfortunate condition written into their genes. These people suffer from familial sleep lead syndrome, a rare condition that causes people to go to bed and get up four hours earlier than others. After studying the behavior of an identified variant protein in cultured human skin cells, the researchers said that the root cause of the syndrome may be a simple protein output from the nucleus.
It is generally believed that the less phosphate modifies the Period2 family protein, the more stable it is, but Kramer and colleagues found that the opposite was true in this condition.
It is found that this phenomenon is caused by the rapid degradation of the protein from the nucleus to the cytoplasm, which is more than twice that of the normal enzyme. "Usually, this protein is produced in the cytoplasm, then enters the nucleus and inhibits its own synthesis," Kramer explained
When it is pumped out of the nucleus again, the inhibition is weakened. The mutant protein goes out of the nucleus faster, so the inhibition is neutralized earlier, resulting in an accelerated cycle. "Going to bed early and getting up early is the first example of human behavior that can really be explained at the protein level," Kramer said Others see the result as a useful step forward. Louis tacek, a sleep geneticist at the University of California, San Francisco, said the results could help us understand "how the precise biological clock is modified". He added that animal experiments could allow us to better study how different phosphate clusters contribute to the protein action of living organisms.
