Some patients taking aspirin for a long time may cause damage to the digestive tract. Aspirin causes gastrointestinal damage as a result of both local and systemic effects. The local effect is the direct stimulation of aspirin to the digestive tract mucosa, which can directly damage the gastric mucosa and also damage the intestinal mucosal barrier. Its systemic effect is to reduce the synthesis of prostaglandins, which can regulate gastrointestinal blood flow, stimulate the synthesis and secretion of mucus and bicarbonate, and protect gastric mucosa.
If you take aspirin enteric coated tablets, there is an acid resistant coating on the outside. The environment inside the stomach is acidic. The acid resistant coating can protect the acid environment inside the stomach from being dissolved and released, and then it can be slowly released and absorbed in the alkaline environment of the small intestine, thus reducing the direct irritation to the gastric mucosa and adverse reactions of the gastrointestinal tract. Therefore, aspirin enteric coated tablets are recommended to be taken on an empty stomach. Furthermore, taking on an empty stomach can shorten the retention time in the stomach and smoothly reach the absorption site of the small intestine, avoiding gastrointestinal adverse reactions caused by prolonged retention time in the stomach. But if aspirin enteric coated tablets are not used, but regular aspirin tablets, there is no protective mechanism above, and such aspirin should be taken after meals.
What time does fasting and after meals specifically refer to?
Taking medication on an empty stomach actually refers to one hour before or two hours after eating. Taking medication after meals does not mean taking medication immediately after eating, but taking it 15-30 minutes after eating.
Should aspirin be taken in the morning or at night?
This issue is currently unresolved. Some experts believe that platelet viscosity is higher and the risk of thrombosis is higher at night. To exert the antiplatelet effect of aspirin, it should be taken at night; Some experts also believe that the risk of cardiovascular risk events occurring in the morning is high, and to prevent cardiovascular risk events, it should be taken in the morning.
Aspirin exerts its antiplatelet effect by irreversibly inhibiting epoxidase and can exist throughout the entire life cycle of platelets (about 10 days). Once it takes effect, the antiplatelet effect is sustained. So, aspirin can be taken at any time of the day (morning, noon, or evening), and it is important to take it regularly at the same time every day.
Can aspirin be taken separately?
In most cases, aspirin enteric coated tablets cannot be broken off for use, because the coating on the outside plays a protective role in gastric mucosa. If broken off, the coating on the surface will be damaged, and the protection of enteric coated tablets will be lost. If the dosage is relatively large, smaller specifications of aspirin enteric coated tablets can be replaced.
When can I chew it up?
When self rescue from myocardial infarction, it is necessary to chew and take. Proper pre hospital emergency treatment is one of the key factors in reducing the mortality rate of myocardial infarction. If there are elderly people over 50 years old or patients with coronary heart disease at home, aspirin should be regularly prepared and carried with them when going out.
The typical symptoms of myocardial infarction are pain in the middle or left part of the sternum, a feeling of impending death, compression, and may be accompanied by symptoms such as sweating and nausea. When a patient is suspected of developing a myocardial infarction, they can immediately chew and take 300 milligrams of aspirin and call 120. At this time, chewing aspirin enteric coated tablets can quickly disintegrate the drug, speed up absorption, and make it play an antiplatelet role faster. In addition, chewed aspirin can also be taken before undergoing coronary stenting surgery to achieve rapid effects.
