Small cell lung cancer is known as the "most refractory lung cancer" because of its high degree of malignancy, easy recurrence and metastasis. They called on people with small cell lung cancer to stay away from tobacco or quit smoking as soon as possible, which can play a role in the prevention of small cell lung cancer.
Medical information network learned that small cell lung cancer accounts for only 15% of the total number of lung cancer, but it is the most invasive type of lung cancer, with high degree of malignancy, rapid cell proliferation and rapid progress. "Patients with small cell lung cancer will have distant metastasis of cancer cells in the early stage. Two thirds of patients are in the advanced stage when they are first diagnosed. These patients are also known as patients with extensive small cell lung cancer. Their cancer cells often spread to the whole lung or other parts of the body." Wu Gang introduced that in clinical treatment, the last thing many doctors want to face is small cell lung cancer.
"Among all pathogenic factors, smoking is the most important possibility," Pan Yueyin said. Among the people with small cell lung cancer, 95% are smokers or people with a history of smoking; Secondly, the greater the amount of smoking, the more likely it is to get sick; In addition, epidemiological and clinical studies have found that the risk of small cell lung cancer decreases most significantly between people who quit smoking and those who did not quit smoking.
The experts reviewed the treatment of small cell lung cancer in the past century. Over the past few decades, in the field of lung cancer treatment, although new therapeutic drugs and methods have emerged one after another, patients' quality of life and survival time have been significantly improved. Unfortunately, these achievements are reflected in patients with non-small cell lung cancer, and small cell lung cancer is still a "hard bone".
"Fortunately, after surgery, radiotherapy, chemotherapy and targeted therapy, immunotherapy has gradually popularized in China in the past five years and has become the fifth mainstream treatment for tumors. Some prefecture level cities in our province have also carried out new therapies one after another." Wu Gang said that immunosuppressants will first mobilize the immune function of T cells in the body to attack tumors, Instead of immunosuppressants directly killing tumor cells.
What excites the patients is that the first-line treatment of extensive small cell lung cancer with PD-L1 immunosuppressant combined with chemotherapy has successfully broken the long-term survival dilemma of the disease, so that the median overall survival can be calculated in "years", which is a major breakthrough in the treatment of small cell lung cancer in the past 40 years. Wu Gang said: "In the era of chemotherapy, the 3-year survival rate of patients with extensive small cell lung cancer is less than 6%. Immunotherapy has enabled nearly 18% of patients to obtain an overall survival of more than 3 years, achieved a three-time increase in the 3-year survival rate, and set a new record of long-term survival benefits for patients with extensive small cell lung cancer. In addition, patients with brain metastasis and liver metastasis also show a new trend under this immunotherapy To the benefit trend. "
"Despite the progress of medicine, disease prevention is more than cure. Staying away from tobacco or quitting smoking as soon as possible can play a certain role in the prevention of small cell lung cancer." Pan Yueyin reminded that regular physical examination is very key. When there are symptoms such as cough, hoarseness and dyspnea, see a doctor as soon as possible.
