Inflammatory bowel disease attacks quickly and makes patients miserable. Recently, British researchers found the key factors causing inflammatory bowel disease. Now let's take a look at the key factors caused by inflammatory bowel disease!
Recently, a British research team found that a protein called T-bet plays an important role in maintaining the delicate balance between the intestinal immune system and intestinal flora. Experiments show that the deletion of this protein can lead to symptoms similar to human inflammatory bowel disease (IBD) in mice. Therefore, the researchers believe that the way the protein affects the intestinal immune system can be used as a research direction, and finally pave the way for the development of new methods for the treatment of inflammatory bowel disease. The relevant research results were published in the online edition of the latest issue of the Journal of immunology.
Inflammatory bowel disease refers to ulcerative colitis and Crohn's disease. This disease is common in western countries, and the prevalence rate in China has also begun to rise sharply in recent years. The etiology of inflammatory bowel disease is still unclear, but most studies have targeted the intestinal immune system. A large number of bacteria are parasitic in the human intestine, which plays an important role in maintaining human health. Under normal circumstances, the intestinal immune system will not respond to the activities of beneficial bacteria in the intestine, but only play a role when the internal balance is destroyed. The intestinal immune system of patients with inflammatory bowel disease is different. It will make an immune response to the beneficial flora in the intestine, leading to chronic inflammation.
In a research project funded by the British Medical Research Council and the Wellcome foundation, the research team led by Professor Graham Lord of King's College London found that a protein called T-bet has a strong influence on the interaction between cells of the intestinal immune system. The deletion of this protein will lead to the dysfunction of immune cells, cause inflammation and eventually lead to the occurrence of inflammatory bowel disease. Experiments have proved that once the T-bet protein in the mouse immune system is removed, it will lead to the symptoms similar to human inflammatory bowel disease in mice; Using these proteins as therapeutic targets can reverse the symptoms of inflammatory bowel disease in mice.
The researchers pointed out that their research is of great significance to confirm the immune cell and molecular processes that can lead to inflammatory bowel disease for the first time; The enhancement of T-bet protein
